Author's response to reviews Title: Physicochemical analysis of blood and urine in the course of acute kidney injury in critically ill patients: a prospective, observational study Authors:

Physicochemical analysis of blood and urine in the course of acute kidney injury in critically ill patients: a prospective, observational study

BACKGROUND Sequential physicochemical alterations in blood and urine in the course of acute kidney injury (AKI) development have not been previously described. We aimed to describe these alterations in parallel to traditional renal and acid-base parameters. METHODS One hundred and sixty eight consecutive critically ill patients with no previous kidney disease, who had an indwelling urinary ca...

Author's response to reviews Title: Epidemiology of acute kidney injury in Hungarian intensive care units: a multicenter, prospective, observational study Authors:

Pharmacokinetic Behavior of Theophylline following PEEP in Critically Ill Patients with Acute Lung Injury

The effect of Positive End Expiratory Pressure (PEEP) on the hepatic elimination of low to moderate extraction ratio drugs has not been clearly defined. We prospectively investigated the effect of PEEP on the clearance of theophylline in 30 (20 males and 10 females) intubated critically ill adult patients with acute lung injury/acute respiratory distress syndrome (ALI/ARDS). The Mean (±SD) age ...

Author's response to reviews Title: Neutrophil Gelatinase-Associated Lipocalin (NGAL) predicts Renal Injury in Acute Decompensated Cardiac Failure: A prospective observational study Authors:

Comparison of the effect of Coenzyme Q10 and N-acetyl cysteine in prevention of acute kidney disease in critically ill patients admitted to Pediatric Intensive Care Unit

Background: Acute renal injury (AKI) is one of the most common causes of mortality in children admitted to intensive care units (PICU). Here, we investigated the preventive effect of N-acetylcysteine ​​(NAC) and Coenzyme Q10 on AKI among children admitted to PICU. Methods: This double-blind randomized clinical trial study was done on 78 children admitted to PICU in 2018. Patients were randomly...